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2nd International Conference on Cancer Biology, Therapeutics and Drug Discovery & Delivery, will be organized around the theme “ Latest discoveries and innovations in the field of Cancer Biology & Drug Delivery”
Cancer Biology 2018 is comprised of 21 tracks and 129 sessions designed to offer comprehensive sessions that address current issues in Cancer Biology 2018.
Submit your abstract to any of the mentioned tracks. All related abstracts are accepted.
Register now for the conference by choosing an appropriate package suitable to you.
Cancer frameworks science includes the utilization of frameworks science ways to deal with tumor inquire about, keeping in mind the end goal to ponder the illness as a complex versatile framework with rising properties at different natural scales. All the more unequivocally, in light of the fact that growth traverses numerous organic, spatial and transient scales, correspondence and input instruments over the scales make a profoundly complex dynamic framework. The connections between scales are not basic or fundamentally immediate, and now and again wind up noticeably combinatorial, so frameworks approaches are basic to assess these connections quantitatively and subjectively. Malignancy frameworks science hence receives an all-encompassing perspective of growth went for incorporating its numerous organic scales, including hereditary qualities, flagging systems, epigenetics, cell conduct, histology, (pre)clinical indications and the study of disease transmission.
- Track 1-1Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics
- Track 1-2Research on Causes of Cancer
- Track 1-3Opportunities in Cancer Biology Research
- Track 1-4Statistical and mechanistic modelling of cancer progression and development
- Track 1-5Cancer therapeutic resistance
- Track 1-6Cancer Genomics
- Track 1-7Microbes Meet Cancer
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease.
- Track 2-1Cancer and Cell Biology
- Track 2-2A matter of life and death: stem cell survival in tissue regeneration and tumors formation
- Track 2-3Stem cells: Bio banking breast cancers
- Track 2-4Can Stem cells turn into cancer?
- Track 2-5The cancer stem cell Markers
- Track 2-6Embryonic Cancer Stem Cells
Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the "process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. If a regenerated organ's cells would be derived from the patient's own tissue or cells, this would potentially solve the problem of the shortage of organs available for donation, and the problem of organ transplant rejection. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differentiation (cell therapies); the induction of regeneration by biologically active molecules administered alone or as a secretion by infused cells (immunomodulation therapy); and transplantation of in vitro grown organs and tissues (tissue engineering).
- Track 3-1Bone marrow transplant
- Track 3-2Stem Cell Transplants May Work Better Than Existing Drug for Severe Multiple Sclerosis
- Track 3-3Skin Tissue Engineering: Was it Really So Simple a Challenge...?
- Track 3-4Stem cell therapies and neurological disorders of the brain: what is the truth?
- Track 3-5Current Applications of Tissue Engineering in Biomedicine
- Track 3-6Endogenous Cardiac Stem Cells
- Track 3-7Engineering Approaches to Regenerating Damaged Neural Tissue
- Track 3-8Transplantation of Embryonic Stem Cell-Derived Progenitor Cells for CNS Repair
An oncogene is a gene that has the potential to cause cancer. In tumor cells, they are often mutated and/or expressed at high levels. Most normal cells will undergo a programmed form of rapid cell death (apoptosis) when critical functions are altered and malfunctioning. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. Most oncogenes began as proto-oncogenes, normal genes involved in cell growth and proliferation or inhibition of apoptosis. If normal genes promoting cellular growth, through mutation, are up-regulated, (gain of function mutation) they will predispose the cell to cancer and are thus termed oncogenes. Usually multiple oncogenes, along with mutated apoptotic and/or tumor suppressor genes will all act in concert to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target the proteins encoded by oncogenes.
- Track 4-1Oncogene
- Track 4-2Neuroendocrine Carcinoma
- Track 4-3Neuroblastoma
- Track 4-4Osteosarcoma
Cancer Technologies are those technical innovations which represent progressive developments within a field for competitive advantage.
- Track 5-1Humanized immune system and immune-oncology in the SRG rat
- Track 5-2Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice
- Track 5-3Aging immune system may explain age-related cancer risk increase
- Track 5-4Bacteria play critical role in driving colon cancers
- Track 5-5Nanotechnology: an evidence-based analysis
Innovation can be defined simply as a "new idea, device or method". However, innovation is often also viewed as the application of better solutions that meet new requirements, unarticulated needs, or existing market needs. This is accomplished through more-effective products, processes, services, technologies, or business models that are readily available to markets, governments and society. The term "innovation" can be defined as something original and more effective and, as a consequence, new, that "breaks into" the market or society. It is related to, but not the same as, invention, as innovation is more apt to involve the practical implementation of an invention to make a meaningful impact in the market or society, and not all innovations require an invention. Innovation is often manifested via the engineering process, when the problem being solved is of a technical or scientific nature. The opposite of innovation is exnovation.
- Track 6-1Genetically engineered probiotic that targets and kills cancer cells in the gut
- Track 6-2Identified a way to turn a humble cocktail of bacteria and vegetables into a targeted system that finds and kills colorectal cancer cells.
- Track 6-3Anticancer Activity of Guava (Psidium guajava) extracts
- Track 6-4The first humanized immune system rat
- Track 6-5Lab-grown mini lungs successfully transplanted into mice
Molecular genetics is the field of biology that studies the structure and function of genes at a molecular level and thus employs methods of both molecular biology and genetics. The study of chromosomes and gene expression of an organism can give insight into heredity, genetic variation, and mutations. This is useful in the study of developmental biology and in understanding and treating genetic diseases
- Track 7-1Immune disorders
- Track 7-2Molecular Immunology
- Track 7-3Cancer and Haematology
- Track 7-4New vulnerability revealed in blood cancer development
- Track 7-5Gene therapy
- Track 7-6Human Genome
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, or may result from such factors as disease, localized injury, or the death of the organism of which the cells are part. Kinds of cell death include the following. Programmed cell death (or PCD) is cell death mediated by an intracellular program. PCD is carried out in a regulated process, which usually confers advantage during an organism's life-cycle. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose; the result is that the digits are separate. PCD serves fundamental functions during both plant and metazoa (multicellular animals) tissue development.
- Track 8-1Cell of origin provides clues for early detection of lung cancer
- Track 8-2Application and expansion of optogenetics, a technique to control brain cell activity with light
- Track 8-3An enzymes involved in cell growth and metabolism
- Track 8-4Identify a key protein for regulating immune response
- Track 8-5Drug Sensitivity of Resistant Leukemia Cell Lines
- Track 8-6Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis
Cancer bioinformatics is a critical and important part of the systems clinical medicine in cancer and the core tool and approach to carry out the investigations of cancer in systems clinical medicine. “Thematic Series on Cancer Bioinformatics” gather the strength of BMC Bioinformatics, BMC Cancer, Genome Medicine and Journal of Clinical Bioinformatics to headline the application of cancer bioinformatics for the development of bioinformatics methods, network biomarkers and precision medicine. The Series focuses on new developments in cancer bioinformatics and computational systems biology to explore the potential of clinical applications and improve the outcomes of patients with cancer.
- Track 9-1Structural Bioinformatics
- Track 9-2Gene Expression
- Track 9-3DNA Technology
- Track 9-4Genomics
- Track 9-5Biomedical engineering
Cancer is a group of diseases that involve abnormal increases in the number of cells, with the potential to invade or spread to other parts of the body. Not all tumors or lumps are cancerous; benign tumors are not classified as being cancer because they do not spread to other parts of the body.There are over 100 different known cancers that affect humans
- Track 10-1Lung Cancer
- Track 10-2Breast Cancer
- Track 10-3Brain Cancer
- Track 10-4Cervical Cancer
- Track 10-5Ovarian Cancer
- Track 10-6Prostate Cancer
- Track 10-7Pancreatic Cancer
There are several methods of diagnosing cancer. With advances in technologies that understand cancers better, there is a rise of number of diagnostic tools that can help detect cancers. Once suspected, diagnosis is usually made by pathologists and oncopathologists and imaging radiologists.Some types of cancer, particularly lymphomas, can be hard to classify, even for an expert. Most cancers need a second opinion regarding diagnosis before being sure of the diagnosis or stage and type.
- Track 11-1How Is Cancer Diagnosed?
- Track 11-2Genomic tumor assessment
- Track 11-3Mind/Body Medicine for Cancer
- Track 11-4Homeopathy and Cancer
- Track 11-5Tumor Markers
- Track 11-6Sentinel Lymph Node Biopsy
- Track 11-7Genomic testing
- Track 11-8Bone marrow aspiration
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells. These white blood cells are not fully developed and are called blasts or leukemia cells. Symptoms may include bleeding and bruising problems, feeling tired, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy. The exact cause of leukemia is unknown. A combination of genetic factors and environmental (non inherited) factors are believed to play a role. Risk factors include smoking, ionizing radiation, some chemicals (such as benzene), prior chemotherapy, and Down syndrome. People with a family history of leukemia are also at higher risk. There are four main types of leukemia acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) as well as a number of less common types. Leukemias and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system, known as tumors of the hematopoietic and lymphoid tissues.
- Track 12-1Communication between Lung Tumors, Bones Contributes to Tumor Progression
- Track 12-2Misregulated Protein Breakdown Promotes Leukemias and Brain Cancer
- Track 12-3Modular Gene Enhancer Promotes Leukemia
- Track 12-4HLF-Gene Controls Generation of Our Long-Term Immune System
- Track 12-5Important Mechanism of Epigenetic Gene Regulation Identified
- Track 12-6Bolstering Fat Cells Offers Potential New Leukemia Treatment
- Track 12-7A new CRISPR-engineered cancer model to test therapeutics
Cancer genetics is the study in humans and other animals of heritable gene variants that cause or confer altered risk of tumour or hematological malignancy. Individual cancer risk varies and is influenced by familial and sporadic oncogene or tumour suppressor gene mutations as well as rare and common constitutional variants present in the population.
- Track 13-1Role of a DNA Repair Mechanism
- Track 13-2Insights from a Rare Genetic Disease May Help Treat Multiple Myeloma
- Track 13-3Study Links Mutations in Notch Gene to Role in B Cell Cancers
- Track 13-4Isolation of a gene coding for part of the T-cell receptor, a key to the immune system’s function
- Track 13-5First use of gene expression profiling to predict cancer outcomes
- Track 13-6Cancer Genetic Mutations
- Track 13-7Mitochondrial DNA may play more important role in metastatic cancer than previously thought
A biopharmaceutical, also known as a biologic(al) medical product, biological, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines, blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living cells used in cell therapy. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living cells or tissues. They (or their precursors or components) are isolated from living sources—human, animal, plant, fungal, or microbial.
- Track 14-1Renal Cell Cancers
- Track 14-2Cancer drugs
- Track 14-3New Cancer Vaccines
- Track 14-4Generic chemotherapy drug
- Track 14-5Lipid Complex Injection for Cancer
- Track 14-6Cancer Chemo and Biologic Drugs
A tumor marker is a biomarker found in blood, urine, or body tissues that can be elevated by the presence of one or more types of cancer. There are many different tumor markers, each indicative of a particular disease process, and they are used in oncology to help detect the presence of cancer. An elevated level of a tumor marker can indicate cancer; however, there can also be other causes of the elevation (false positive values).Tumor markers can be produced directly by the tumor or by non-tumor cells as a response to the presence of a tumor. Although mammography, ultrasonography, computed tomography, magnetic resonance imaging scans, and tumor marker assays help in the staging and treatment of the cancer, they are usually not definitive diagnostic tests. The diagnosis is mostly confirmed by biopsy.
- Track 15-1Genomic biomarker
- Track 15-2Imaging biomarker
- Track 15-3Drug activity markers
- Track 15-4Transcriptomic biomarker
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial.
- Track 16-1Stem Cells Found to Minimize Risks When Used to Treat Damaged Hearts
- Track 16-2Stem cell treatments Anti- Aging
- Track 16-3Stem Cells and Regenerative Medicine for Osteoarthritis
- Track 16-4Role of Stem Cells in Treatment of Neurological Disorders
- Track 16-5Stem cell treatments Brain tumor
- Track 16-6Big clues about the life and death of stem cells
- Track 16-7New Type of Stem Cell Line Produced Offers Expanded Potential for Research and Treatments
- Track 16-8First Skin-to-Eye Stem Cell Transplant in Humans Successful
Increase in cases of various cancers has encouraged the researchers to discover novel, more effective drugs from plant sources. This study is a review of medicinal plants in Iran with already investigated anticancer effects on various cell lines. There are medicinal plants alongside their products with anticancer effects as well as the most important plant compounds responsible for the plants' anticancer effect were introduced. Phenolic and alkaloid compounds were demonstrated to have anticancer effects on various cancers in most studies. The plants and their active compounds exerted anticancer effects by removing free radicals and antioxidant effects, cell cycle arrest, induction of apoptosis, and inhibition of angiogenesis. The investigated plants in Iran contain the compounds that are able to contribute effectively to fighting cancer cells.
- Track 17-1Medicinal Plants: Their Use in Anticancer Treatment
- Track 17-2Anti-Cancer Herbs and Plants
- Track 17-3Artemisia Annua
Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells—ectoderm, endoderm and mesoderm (see induced pluripotent stem cells)—but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.
- Track 18-1Adult Stem Cells (ASCs) and Types
- Track 18-2Embryonic Stem Cells (ESCs)
- Track 18-3Induced Pluripotent Stem Cells (iPSCs)
- Track 18-4Stem cells bioprocessing: an important milestone to move regenerative medicine research into the clinical arena
- Track 18-5Tissue engineering and regenerative medicine: manufacturing challenges
- Track 18-6Regenerative pharmacology: the future is now
Cancer can be treated by surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy and synthetic lethality. The choice of therapy depends upon the location and grade of the tumor and the stage of the disease, as well as the general state of the patient. A number of experimental cancer treatments are also under development. Under current estimates, two in five people will have cancer at some point in their lifetime. Complete removal of the cancer without damage to the rest of the body (that is, achieving cure with near-zero adverse effects) is the ideal goal of treatment and is often the goal in practice. Sometimes this can be accomplished by surgery, but the propensity of cancers to invade adjacent tissue or to spread to distant sites by microscopic metastasis often limits its effectiveness; and chemotherapy and radiotherapy can have a negative effect on normal cells. "Cancer" refers to a class of diseases; it is unlikely that there will ever be a single "cure for cancer" any more than there will be a single treatment for all infectious diseases. Angiogenesis inhibitors were once thought to have potential as a "silver bullet" treatment applicable to many types of cancer, but this has not been the case in practice
- Track 19-1Radiation Therapy
- Track 19-2Chemotherapy
- Track 19-3Immunotherapy
- Track 19-4Targeted Therapy
- Track 19-5Hormone Therapy
- Track 19-6Precision Medicine
Probiotics are microorganisms that many believe provide health benefits when consumed. The term probiotic is currently used to name ingested microorganisms associated with benefits for humans and animals. The term came into more common use after 1980. The introduction of the concept (but not the term) is generally attributed to Nobel laureate Élie Metchnikoff, who postulated that yogurt-consuming Bulgarian peasants lived longer lives because of this custom. He suggested in 1907 that "the dependence of the intestinal microbes on the food makes it possible to adopt measures to modify the flora in our bodies and to replace the harmful microbes by useful microbes". A significant expansion of the potential market for probiotics has led to higher requirements for scientific substantiation of putative benefits conferred by the microorganisms.
- Track 20-1The Role of Probiotics in Cancer Treatment
- Track 20-2Probiotics and colon cancer
- Track 20-3Lactic acid bacteria and cancer: mechanistic perspective
- Track 20-4Probiotics supplements
- Track 20-5Probiotics tablets
Medication conveyance alludes to approaches, plans, advances, and frameworks for transporting a pharmaceutical compound in the body as expected to securely accomplish its coveted restorative effect. It might include logical site-focusing inside the body, or it may include encouraging fundamental pharmacokinetics; regardless, it is commonly worried about both amount and length of medication nearness. Medication conveyance is regularly drawn closer by means of a medication's synthetic definition; however it might likewise include medicinal gadgets or medication gadget mix items. Medication conveyance is an idea vigorously coordinated with measurement shape and course of organization, the last here and there being considered piece of the definition. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms.
- Track 21-1Thin film drug delivery
- Track 21-2Retrometabolic drug design
- Track 21-3Bovine submaxillary mucin coatings
- Track 21-4Drug carrier
- Track 21-5Drug delivery to the brain
- Track 21-6Neural drug delivery systems
- Track 21-7Acoustic targeted drug delivery
- Track 21-8Self-microemulsifying drug delivery system
- Track 21-9Magnetic drug delivery
- Track 21-10Asymmetric membrane capsule