3rd International Conference on Cancer Biology & Anti-Cancer Therapies and Drug Development & Delivery
Andrei L. Gartel
University of Illinois
Andrei L. Gartel, Ph.D., is an Associate Professor in the Department of Medicine at the University of Illinois at Chicago and is the Academic Editor of PLOS ONE. He is the author of 92 peer-review publications that include more than 20 reviews. He has more than 14,000 citations and his h-index 41. Earlier, his major contribution to the field was a discovery that c-Myc negatively regulates transcription of the CDK inhibitor p21 via interaction with transcription factors Sp1/Sp3 (more than 400 citations). In addition, his laboratory discovered the presence of alternate p21 transcripts that are strongly regulated by p53 in human and mouse cells. We found a positive auto-regulation loop of the oncogenic transcription factor FOXM1 and negative regulation of FOXM1 by tumor suppressor p53. His lab also found a positive auto-regulation loop of the oncogenic transcription factor FOXM1 and negative regulation of FOXM1 by tumor suppressor p53. He received his funding from NIH, DOD and private companies/foundations.
Abstract : Global importance of FOXM1 in human cancer